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Bioreactor for cultivating cells and protein expression


The cell culture flask CELLine is a disposable bioreactor based on two-compartment technology. It allows to cultivate cells at highest densities (107–108 cells/ml) and to express proteins like monoclonal antibodies at very high concentrations.

The bioreactor CELLine is separated into a medium and a cell compartment by means of a 10 kDa semi-permeable membrane. This membrane allows a continuous diffusion of nutrients into the cell compartment with a concurrent removal of any inhibitory waste product. The individual accessibility of the compartments allows supplying cells with fresh medium without mechanically interfering with the culture. Optimal oxygen supply and control of carbon dioxide levels is ensured by a silicone membrane which forms the cell compartment base.


Product features

High Quality

Expression of proteins at concentrations 50 times higher than with standard culture flask.

Cost reduction

Less consumption of supplements like serum, therefore reducing costs.

Satisfied customers

That's why we do it

"At NBS Scientific I got quick and reliable responses to questions and appointments. All advice and attention was expertly given. We've been happily working together for over 2 years now. "

I experience NBS Scientific as an excellent partner with pleasant employees. I have good contact with them.

Charles River Laboratories

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